Application of spray dryer in biopharmaceutical industry

The drying process is a process that is often used in modern industry. Rapid and effective drying has been an indispensable tool for production, and spray dryer is the most widely used technology in the process of liquid forming and drying industry.
Its advantage is not only reflected in the speed, but also to have some special requirements in the drying process, such as product size distribution, residual moisture content and so on, are able to meet the requirements of the precision standard. Therefore, the solid dispersion agent / solution can be achieved by the use of spray dryer.
Especially in the bio pharmaceutical industry, for the production of drugs, in all aspects of production requirements are very strict. The effective temperature range for drying is very limited for those who have been shown to be thermoplastic and have a lower conversion temperature. Two contradictory factors determine the limited temperature range: the product temperature must be low enough to ensure the stability of the product and not binding; at the same time, the drying temperature must be high enough so that the material in droplet / particle collision time effective drying material within the wall before the drying tower. To make matters worse, the solvent in the material acts as a plasticizer, reducing the allowable temperature of the product. The wrong drying conditions will result in very low yield due to the wall material, and the low and high drying temperature will result in this result. For the above requirements, spray dryer can meet and achieve it?
In the dry, for the drying of different substances, to consider a lot of factors. The drying of the particles should be determined by the outlet temperature of the dryer and the solvent vapor content in the exhaust. Higher outlet temperature or lower solvent vapor content will affect the drying of the product. For a fixed spray dryer outlet temperature and dry gas flow, reducing the inlet temperature of the dryer will lead to the decline of feed quantity, evaporation, and the decrease of the solvent vapor content. Therefore, it is necessary to carefully balance the spray drying parameters.
In addition to the above factors, in fact, spray dryer can produce effective drying time is also very important. Because of the different products, when dry, when its own residual solvent diffusion is constrained, a single stage drying machine can not be effective drying, in many cases must be added additional drying section.
Of course, although the effect of this drying method is very good, but not all drugs can in the spray dryer for drying, this is because some drugs with thermoplastic, will lead to the unsuitable in this dry way. At this time, low pressure spray drying can be a choice.